Publications

Evaluating Personal and Environmental Decolonization Strategies for Children with Skin and Soft Tissue Infection and Their Households - A Randomized Clinical Trial.

Staphylococcus aureus colonization predisposes to skin and soft tissue infection (SSTI). Given the waning effectiveness of decolonization, we evaluated periodic personal decolonization and household environmental decontamination to reduce SSTIs among households affected by S. aureus.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Evaluating the Implementation of a Workplace Weight Loss Program Using a Modified Process Evaluation Rating Sheet.

To demonstrate the utility of a modified Process Evaluation Rating Sheet (PERS) for analyzing implementation quality and program efficacy in a workplace weight loss program.

Journal of occupational and environmental medicine

The Knight Alzheimer Research Imaging (KARI) dataset: a comprehensive multimodal resource for exploring aging, preclinical, and symptomatic Alzheimer disease pathology.

Alzheimer disease (AD) remains a significant global public health challenge, requiring robust multimodal datasets to elucidate its prolonged preclinical phase, improve early detection, advance understanding of disease trajectories, and guide intervention strategies. To address this, the Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC) at Washington University in St. Louis established the Knight Alzheimer Research Imaging (KARI) dataset. This paper characterizes this dataset emphasizing its phenotypical depth and longitudinal scope, detailing comprehensive multimodal neuroimaging from 1,645 participants (aged 42-97) across 6,217 acquisitions. Spanning the AD spectrum from healthy aging to symptomatic disease, the cohort undergoes extensive longitudinal imaging using structural and functional magnetic resonance imaging (MRI) alongside positron emission tomography (PET) tracers for amyloid and tau pathology. This is complemented by rich clinical, cognitive, genetic, and biomarker data. In addition to raw imaging, the dataset provides quality-controlled processed outputs, including anatomical segmentations and biomarker quantification. By making this data accessible to researchers, the Knight ADRC aims to accelerate discoveries in pathophysiology, biomarker identification, and therapeutic development.

Research square

Study Designs and Methods for Health Policy and Health Services Research: A Look Back, A Look Ahead.

JAMA health forum

Active learning-guided catalyst design for selective acetate production in CO electroreduction

Acetic acid is an essential chemical with industrial and consumer relevance, but its manufacture has significant environmental impacts. Electrochemical CO reduction reaction (CORR) over Cu offers a sustainable route to acetate from waste carbon, but identifying appropriate catalysts is challenging. This paper offers a data-driven catalyst design strategy.

Nature Communications

Assessing the usability of a novel toolkit for creating visual key information pages for informed consent for research: mixed methods usability study

Key information pages for informed consent require a concise summary of information but have not widely incorporated health literacy best practices. In this study, we conducted usability testing of a customizable one-page key information template. Overall, participants considered the toolkit to be appropriate, acceptable, and feasible.

JMIR Formative Research

Exploring factors contributing to patient decision-making in the care journey to elective hernia care in Kenya.

Capacity for elective general surgical care is an important reflection of a health system's ability to meet a population's surgical needs and is currently known to be inadequate in many low- and middle-income countries. Patient agency is a key, understudied factor which shapes how and when patients ultimately decide to engage with formal care. Understanding factors which influence patient care seeking activity can have important implications for how current and future health systems may be utilized. This study aims to explore how patients approach the navigation and triage of their elective hernia condition within the Kenyan surgical care system.

PloS one

Challenges in Achieving US Population Awareness of Alcohol as a Carcinogen: Identifying Predictors of Continued Lack of Awareness After Educational Video Exposure.

Alcohol use increases the risk of seven cancers, including breast and colorectal cancers. Awareness of this is low in the US population (34%), which impedes risk reduction efforts, support for alcohol regulation policies, and physician and family communication about this topic. Efforts to improve awareness of the cancer risks of alcohol will require multiple approaches including the use of educational messages tailored to audience needs. There is a lack of evidence regarding how existing messaging influences awareness, and characteristics associated with awareness that could guide future messaging.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Assessing the Usability of a Novel Toolkit for Creating Visual Key Information Pages for Informed Consent for Research: Mixed Methods Usability Study.

Key information pages for informed consent require a concise summary of information to improve participant understanding but have not widely incorporated health literacy best practices.

JMIR formative research